![]() ![]() 2016) and mood instability (Faurholt et al. It can also be questioned whether the difference in comorbidity with borderline personality disorder (Fornaro et al. For example, it is a matter of debate whether the course of the illness in bipolar II disorder, which is, in comparison to bipolar I disorder, predominantly characterized by depressive symptomatology, may simply be the logical consequence of the fact that the previous disease course of bipolar II disorder, compared to bipolar I disorder, as defined by the diagnostic "inclusion" criteria, also favors the depressive pole. ![]() It also remains an open question whether the diagnosis of bipolar II disorder, although clinically helpful, is indeed an independent, valid disease entity, as postulated by ICD-11-or whether it represents, at least in part, primarily the result of methodological differences concerning the diagnosis of bipolar I and bipolar II disorder.
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