2016) and mood instability (Faurholt et al. It can also be questioned whether the difference in comorbidity with borderline personality disorder (Fornaro et al. For example, it is a matter of debate whether the course of the illness in bipolar II disorder, which is, in comparison to bipolar I disorder, predominantly characterized by depressive symptomatology, may simply be the logical consequence of the fact that the previous disease course of bipolar II disorder, compared to bipolar I disorder, as defined by the diagnostic "inclusion" criteria, also favors the depressive pole. It also remains an open question whether the diagnosis of bipolar II disorder, although clinically helpful, is indeed an independent, valid disease entity, as postulated by ICD-11-or whether it represents, at least in part, primarily the result of methodological differences concerning the diagnosis of bipolar I and bipolar II disorder.
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